Monday, May 23, 2022

Why liver injury after first Remdesivir dose at PGI?

Newborn shows liver injury after first Remdesivir dose at PGI

Why liver injury after first Remdesivir dose at PGI?
Newborn shows liver injury after first Remdesivir dose at PGI


PGI doctors caution against its use in less severe patients

BGA researchers reported a unique case of a 14-day-old Covid-19-positive infant who exhibited liver damage after being injected with Remdesivir, a commonly used drug.in Covid-19 patients in the second wave. The research paper focused on the use of Remdesivir in young patients.

Doctors at the Center for Advanced Paediatrics, PGI, highlighted the newborn's case in an article titled “Remdesivir induced liver injury in a newborn with Covid,” published in the Indian Journal of Pediatrics.

According to the report, a newborn with Covid-19 who was diagnosed with hypoxemia (low oxygen levels) requiring intubation was admitted to the PGI. During the administration of remdesivir, the child developed transaminitis (liver infection) to stop taking the drug, and, the liver enzymes improved within two weeks.

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This 14-day-old infant developed malnutrition, lethargy, and shortness of breath on the 13th day of life. A child diagnosed with congestive heart failure requires continuous cardiopulmonary resuscitation (CPAP). A chest X-ray showed viral pneumonia and the child was positively diagnosed with Covid. The child worsened the complication and was admitted on day 5 of hospitalization.

Due to the severity of Covid pneumonia, the child was treated with Remdesivir. After starting Remdesivir, the child developed liver damage after the first injection.

Researchers say that drug-induced liver damage is different from Covid-19 liver disease and Remdesivir was discontinued after the first dose.

The researchers said that the baby's liver enzymes were gradually normalized on the 15th day of the hospital stay and that the baby was discharged on the 18th day of breastfeeding.

Because liver failure and recovery are associated with temporal association with the initiation and discontinuation of Remdesivir therapy, respectively, it was considered highly unlikely that drug-induced liver damage could occur there a lot, say the doctors.

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Remdesivir has demonstrated shorter hospital stays and modest gains in relative survival and severe Covid infection in adult patients. Remdesivir may increase transaminases and was avoided in patients with pre-existing liver failure. Remdesivir should be used with caution and limited to severe Covid infections, "the paper reads.

Remdesivir has been shown to reduce hospital stay and moderate survival benefit for moderate to severe Covid infections in adult patients. Remdesivir may increase transaminases and should not be used in patients with pre-existing liver failure. Remdesivir should be used with caution and limited to cases of severe Covid infection, "the paper said.

CONCLUSION :-

Newborn shows liver injury after first Remdesivir dose at PGI PGI doctors caution against its use in less severe patients During the administration of remdesivir, the child developed transaminitis (liver infection) to stop taking the drug, and, the liver enzymes improved within two weeks. Researchers say that drug-induced liver damage is different from Covid-19 liver disease and Remdesivir was discontinued after the first dose.

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SOURCE :- TRIBUNE


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